尿酸塩結石発生機転に関する研究 : 第二報 : 電子顕微鏡学的観察
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概要
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Complications of uric acid or urate stones with hyperuricemic kidney are well known. For the purpose of studying the developing mechanisms of urate kidney stone, the author used male rats Wister line of about 150 g body weight and fed them on urate stone meals including oxonic acid potassium salt and uric acid and induced hyperuricemic kidney and urate kidney stone and observed electron microscopically the generation mechanisums of urate stone. The following results were obtained: 1) High dense body (electron opaque material) with processes od 300 mμ-7μ of mainly round, circuloid or columnar or sometimes club-like in shape were observed in glomerular epithelial cells and epithelial cells of proximal tubule and they were considered morphologically as perioxisome (microbody) which includes urate oxidase. 2) Inside the cavity of proximal tubule were observed amorphous or irregular substances of various electron densities, cytoplasmic materials by herniation, decidual cells including high dense body or intracellurlar micro-organs and exfoliating cell bodies by necrosis of epithelial cell. 3) Flowing substances such as homogeneous substances, degenerating substances, decidual cells and others were observed in the canal cavity of Henle's loop. 4) Inside the cavity of the distal tubule, there were observed many leucocytes desides of flowen-down substandes from upper renal tubules, and in leucocyte cells were observed crystal-like stuctures which were supposed to be phagocytized, but urate crystals were not observed. 5) Hyaline casts and cellular casts were observed in the cavity of collecting tubule and urate crystals were observed acattering as rhombic, columnar or round spaces of 50 mμ-2 μ in hyaline casts and urate crystals as rhombic, columnar or pin-shaped spaces of 50 mμ-5 μ were observed in cellular cast and glycoprotein was observed at the margen of crystals. 6) Urate crystals were observed nither in epithelial cells of glomerulus,renal tubules, collecting tubules nor stroma. they were observed only in the lumen of collecting tubule.
- 社団法人日本泌尿器科学会の論文
- 1978-10-20