外科的腎疾患における貧血に就いての研究

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A statistical analysis was done on anemia among 800 cases with various urological diseases. Then 36 cases who showed a red cell count less than 400×10^4 or ahemoglobin level less than 80% were selected, and the relationship between hematological findings and renal functions was studied before and after urological treatments. In rabbits, unilateral ureteral ligation and unilateral nephrectomy with contralateral Goldblatt's operation were performed, and various tests were done including hemoglobin level, red blood cell count, PSP values at 15 and 60 minutes and blood pressure. The following results were obtained. 1) In various urological diseases, RBC was more than 551×10^4 in 1.6%, less than 400×10^4 in 42,1%, and less than 300×10^4 in 7.0%. RBC of less than 400×10^4 was seen more frequently in female, and in older individuals. 2) Malignant tumors in urplogical field, regardless of its location, were complicated with anemia in a considerably higher frequency than benign tumors or non-tumorous lesions. 3) Excluding malignant tumors, anemia was seen the most frequently in bilateral renal diseases, followed by unilateral renal diseases and lower urinary tract diseases. It was seen the least frequently in the diseases without urinary tract lesions. 4) Anemia was mostly normochromic, slightly macrocytic and slightly hypo-saturated. 5) White blood cell count was almost normal, and its differential count showed slight lymphopenia. 6) On bone marrow examination, slight maturation arrest was seen in erythropoiesis and neutropoiesis. No other abnormality was seen. 7) Serum iron was normal or slightly decreased. 8) A positive correlation was recognized between hemoglobin level and PSP values at 120 minutes or RPF or "renal hemoglobin circulating volume", or FF. No correlation was recognized between hemoglobin level and other renal function tests or blood pressure. RBC showed a negative correlation with BUN, and a positive correlation with PSP values at 15 and 120 minutes or RPF or "renal red blood cell circulating volume" or FF. No correlation was recognized between RBC and other renal function tests or blood pressure. Hematocrit values showed a negative correlation with BUN, and a positive correlation with Fishberg's concentration test or RBF or "renal hematocrit circulation volume" or RPF or FF. No correlation was recognized between hematocrit values and other renal function tests or blood pressure. 9) No correlation was recognized between hemoglobin level or RBC and hematuria or serum protein level or urinary protein positivity. 10) An increase in hemoglobin level showed a positive correlation with an improvement in GFR or RBF. No correlation was recognized between an increase in hemoglobin level and an improvement in other renal function tests. A positive correlation was recognized between an increase in RBC and an improvement in GFR or RBF or RPF or FF. No correlation was recognized between an increase in RBC and an improvement in other renal function tests. A positive correlation was recognized between an increase in hematocrit value and a. n improvement in GFR or RBF or RPF. No correlation was recognized between an increase in hematocrit value and an improvement in other renal function tests. II) In rabbits, PSP value decreased, anemia developed and blood pressure elevated on unilateral ureteral ligation. Thereafter, the former two conditions gradually improved, while the blood pressure returned to a normal level rapidly. On unilateral nephrectomy with contralateral Goldblatt's operation, PSP values and anemia changed similarly to those on ureteral ligation. However, its individual variation was significantly large, and relatively severe anemia was developed in some rabbits.
社団法人日本泌尿器科学会の論文

外科的腎疾患における貧血に就いての研究

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