泌尿***疾患におけるフオスフアターゼについての組織化學的並びに生化學的研究 : 第5報家兎腎實質内結核菌注入による白血球並びに血清フオスフアターゼの變動について

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Five mg of tubercle bacilli (Frankfurt human type) were injected into renal parenchym (left side only) of normal adult male rabbits and of rabbits sensibilized with BCG. Then the changes in acid and alkaline phosphatase reactions of neutrophilic leucocytes in peripheral blood smears were followed by the method of Takeuchi et al. at pH 5.6 and pH 9.3. The acid and alkaline phosphatase activity of the serum in these rabbits were also determined by Bodansky modified method at pH 5.6 and pH 9.3. 1) After the injection of tubercle bacilli into kidney, the phosphatase reaction increased in general. The increase was more rapid in rabbits sensitized with BCG, than in normal rabbits. 2) After a removal of affected kidney, the phosphatase reaction of leucocytes increased temporarily. 3.) In rabbits which had experienced the infusion of tubercle bacilli, the phosphatase reaction of leucocytes decreased gradually from six to seven weeks after the injection of the bacilli into kidney. 4) The changes of the phosphatase activity in these rabbits were slight. 5) In the histopathological studies of these rabbits, the serious tuberculous changes were observed in the kidneys injected with tubercle bacilli. 6) From the results, it can be said that the phosphatase reaction of leucocytes in peripheral blood smears may indicate the nature of the tuberculous lesions.
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