腎結核に対する内分泌障害の影響に関する研究 : 殊に両側腎結核に及ぼす脳下垂体機能障害の影響に関する実験的研究

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Number of investigations of kidney tuberculosis in morphological and immunological field, in spite of the recent remarkable development of endocrinology, can not make it possible to clarify the relationship between kidney tuberculosis and endocrine functions. Moreover, it is conceivable that the endocrine mechanism in living organism (hormones) may be a factor for initiating this disease since the tuberculosis can be frequently observed in the puberty stage. In order to clarify that anterior pituitary hormone, functioning as a center in all endocrine systems, may probably affect upon the generation and the development of the tuberculosis, the effect of pituitary dysfunction caused by various methods upon the experimental bilateral kidney tuberculosis in male rats of pure Wistar colony was observed, and simultaneously the mechanism of infection was traced. The pituitary dysfunctions were caused by the following methods. (1) For the purpose to obtain the pituitary hyperfunction the massive administration of anterior pituitary hormone was performed; namely, the author injected the daily cure dose (0.5mg) of anterior hormone obtained from the mammalian pituitary anterior lobe into peritoneal cavity every day. Fujimori et al., Yoshimura et al., and Aoi disclosed that this procedure generated the experimental hyperfunction of anterior lobe. (2) In order to inhibit the pituitary function, parahydroxypropiophenone introduced by Marcel parault, 1949, which is a synthetized inhibitor to pituitary body, was perorally given with daily ' dose of 120 mg every day. (3) As the most precise method the hypophysectomy through external auditory meatus was performed. After the innoculation of human tuberculous bacilli isolated from urine of kidney tuberculosis patients into both kidneys of experimental animals, the change of bodily weight, the macroscopic findings of dissected organs, the quantitative culture of intrarenal tuberculous bacilli, the pathohistological examination and the humoral and tissue resistance to infection were observed, and from these results, it is clear that the pituitary dysfunction gives the worse influence the tuberculosis. The important factor of its mechanism consists in the decrease of tissue resistance in individuals, the increased permeability of tissue, and the inhibition of tissue reaction, but the degree of influence upon tuberculosis is various according to the method used to cause the pituitary dysfunction; namely, the most remarkable effect was observed in hypophysectomy, followed by administration of inhibitor of hypophyseal function, and the slightest effect in massive administration of hypophyseal hormone. Though in the early stage, after innoculation of tuberculous bacilli there might be a significant difference in slight degree between control group and experimental group, this difference, diminished with passing of time. The results can be classified for each experiment as follows. (1) The bodily weight decreased most remarkably in hypophysectomized group but did slightly in hypophysis-inhibited group and in anterior hormone-injected group; namely, in comparison with the decrease of 35g in control group, the administration of anterior hormone caused the increase of 5g, the injection of inhibitor showed the decrease of 90g. and the hypophysectomy resulted in the decrease of 140g. (2) The macroscopic findings revealed no significant difference between anterior hormone group or inhibitor-treated group and control group, but showed clearly the significant difference between hypophysectomized group and control group. (3) The quantitative cultivation of tuberculous bacilli within organ showed that the slight difference among every group could be noticed in amount of proliferation of bacilli until the second week after injection. After three weeks the most remarkable result was observed in hypophy-sectomized group, followed by inhibitor-treated group and the least in anterior hormone group. And the last one showed very slight difference from the control group. (4) Although there was no significant difference between massive administration group and control group, in histological appearance, the inhibitor-treated group revealed severe findings; in all cases the typical tubercles being formed after three weeks. The degree of tubercle and caseation or cavity building: in hypophysectomized group was more remarkable than that in other groups. all the tubercle, being observed after two weeks. The state of tubercle bacilli showed an accordance with the histological findings. The most cases of hypophysectomy frequently revealed bacilli mass. (5) The protective reaction in organism (a) Concerning the effect the humoral resistance, there is no significant difference among every group in agglutination reaction of tuberculin-sensitive erythrocytes and in slide cell culture: the results being irregular and varying markedly. But it is not clear whether this fact is due to hypophyseal dysfunction or individual difference. (b) The tissue permeability increased in each group, especially in hypophysectomized group more than in control group; namely, the decrease of tissue resistance in individual was recognized.

腎結核に対する内分泌障害の影響に関する研究 : 殊に両側腎結核に及ぼす脳下垂体機能障害の影響に関する実験的研究

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