TCA サイクルを中心とした前立腺の代謝についての臨床並びに実験的研究 (第2報)
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The morphogenesis of prostatic hypertrophy has been confirmed in detail to some extent. As for the cause of the disease, various theories have already been reported. Among them, the theory attributing the cause of the disease to abnormality of internal secretion, especially of sex-hormone predominates at present. We have up to date, however, no evidence justifying any of the theories in substance. The tissue of prostatic hypertrophy is distingwished by a very high content of citric acid. A few facts found out in the process of my research, in relation to the metabolism of citric acid are here reported. In dogs fed with citric acid and fumaric acid, we see the citric acid increase in prostate, resulting from the citric acid regeneration hindered, and the lowering of TCA cycle in gereral. When fed with fumaric acid alone, the citric acid increase is remarkably large. Aconitase activities in prostate, after 2-3 weeks of citric acid and fumaric acid feeding, are increased. After 2 months, however, the activities are remarkably decreased. Therefore it is understood that, in prostatic hypertrophy, there is a vicious circle of citric acid increased and aconitase activities decrease, citric acid increase preceeding. The order of citric acid value, high or low in the prostatic hypertropby, is as follows: glandular type fibroglandular type fibrous type. The average aconitase activities value in prostatic hypertrophy is lower than in normal prostate, the former being 24.4 and the latter is 37.0. The aconitase activities order is as follows: fibrous type, fibroglandulor type, glondulor type……just reverse to the citric acid value order classified by histological findings. I measured the activities of Transaminase, in order to know the origin of citric acid in prostatic hypertrophy. Findings : GOT, in comparison with GPT, is exceedingly high. Oxaloacetic acid value in tissues is also exceedingly high. Consequently the inverse reaction of GOT is proceeding. In conclusion, it is confirmed that the citric acid increase in prostatic hypertrophy has reference to the proceeding of the inverse reaction of GOT and TCA cycle hindered by aconitase activities lowered. I measured the high energy in prostatic hypertrophy and got ratio ADP/ATP, larger than in normal phosphate bound prostate. It is presupposed from this ratio that the energy regeneration in prostatic hypertrophy tissues is hindered. By Oxygen consumption experiment, adding parotin, it was found out that parotin promotes TCA cycle regeneration in prostatic tissues, especially it increase the activities of aconitase and isocitric dehydrogenase. Further by the experiment of oxygen consumption, very active when both parotin and ATP are used, it was found out that parotin and ATP would have clinical effect when employed in the treatment of the prostatic hypertrophy.