前立腺腫瘍組織の線維素溶解酵素系について

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By using saline extract and KSCN extract, the authors have confirmed that the tissue of prostatic tumor contains plasminogens of two types (the stable type and the labile type) and each proactivator of them. But there could be obtained no fact to conclude that plasminogen activator of the labile type is derived from the blood in the tissue, and also there could be observed no agent to show the effect of plasminogen, plasmin, or anti-trypsin. The content of tissue activator in prostatic cancer was greater than that in benign prostatic hypertrophy; on the average, the former was 869 units per gram, the latter 494 units per gram. The content of tissue activator in surgical capsule was much greater than that in adenoma; on the average of three cases, the former was 879 units per gram, the latter 636 units per gram. After the anti-androgenic therapy for patients with prostatic cancer, the content of tissue activator was observed to have a tendency to decrease, but the average was still high; 622 units per gram. The authors have discussed the relation between the surgical treatment of the prostate which showed a high concentration of plasminogen activator and the bleeding tendency in it. As a result, it has been considered that the use of ε-ACA (Ipsilon) has a remarkable effect to reduce the bleeding during and after prostatectomy, inhibitting not only general but also local fibrinolysis.
社団法人日本泌尿器科学会の論文