腎腫瘍組織のLDH isozyme並びにGOT isozymeについて

概要

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Lactic dehydrogenase (LDH) isozyme of normal renal tissue in 4 cases, of ischemic renal tissue in 2 cases and of renal-cell-tumor tissue in 12 cases and glutamic oxalacetic transaminae (GOT) isozyme of renal-cell-tumor tissue in 7 cases were examined by the use of columnchromatography with DEAE sephadex A-50. The results were as follows: 1) As to the LDH isozyme pattern of normal renal tissue, LDH_1 occupied about 2/3 of all LDH isozymes of the cortex, and the medulla had both LDH_4 and LDH_5, which were not in the cortex. 2) LDH isozyme patten of the cortex of ischemic kidney was the same as of the cortex of the normal kidney. 3) About a half of renal-cell-tumor tissue had an increase of total LDH activity. The LDH isozyme pattern was not constant. In general, LDH_1 decreased and LDH_4 and LDH_5 increased. 4) The total GOT activity of renal-cell-tumor tissue decreased to 1/2 or 1/3 of the normal renal cortex. But because the decrease of GOTm (in mitochondria) was more remarkably than of GOTs (in supernatant) the ratio of GOTs/GOTm increased to about 5/1 (2/1 in normal). 5) In a case of renal granular cell tumor, LDH isozyme and GOT isozyme of the tumor tissue were almost normal. 6) Considering the meaning of LDH isozyme and GOT isozyme in the metabolism, we can say that the increase of glycolysis and the decrease of respiration are the character of energic metabolism in the tumor cell of the kidney.
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