腎移植についての基礎的研究 : 自家, 同種あるいは異種血液で体外灌流を行った腎の変化についての実験的研究

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Since the middle of nineteenth century, the extracorporeal normothermic perfusion of the isolated kidney has already been started by using the heart-lung-kidney preparation. It has been particularly used as a vehicle for the physiological and pharmacological studies. Lately the extracorporeal perfusion of the kidney during the renal transplantation has become necessary for the purpose of preservation of the organ and a number of reports on the functional capacity or viability of the perfused kidney have appeared. However there are very few reports on the renal hemodynamics discussed from the stand point of transplantation immunity when the isolated kidney was perfused with the auto-, homo-, or heterologous blood. In the present paper the author used the extracorporeal perfusion apparatus (MERA C type roller pump, disc type oxygenator) for the perfusion of isolated kidneys and tried to produce an identical experimental condition each time in order to avoid several technical problems and specific or unspecific vital-reactions occurring during the renal transplantation. Each of isolated dog kidneys was perfused with the auto-, homo-, orheterologous blood; 3, 7, and 4 cases respectively. The perfusate consisted of the auto-, homo-, orheterologous blood 350 ml, 20 % mannitol 100 ml, aminophyllin 1.0 g and heparin 50 mg. The changes in those kidneys were investigated by using the autologous blood perfused group as a control and the following results were obtained.
社団法人日本泌尿器科学会の論文

腎移植についての基礎的研究 : 自家, 同種あるいは異種血液で体外灌流を行った腎の変化についての実験的研究

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