4-Nitroquinoline 1-Oxideのラット前立腺に対する造腫瘍作用について

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Reports on experimental tumor in the prostate date back to 1937, when Moore et al. artificially made a squamous cell carcinoma in the prostate of rats with 1:2-Benzpyrene. Since then many reports have been published on this subject in the United States and European countries. In contrast, in Japan, only Takenaka published a report in 1964 with reference to this theme. No report has so far been made on the experimental tumor of prostate induced with 4-nitroquinoline 1-Oxide (4 NQO). In the present study, the tumorogenic action of 4 NQO on the prostate of rats was evaluated on male Wistar strain rats. Particular attention was paid to the following 3 points: 1)presence of tumorogenic action, 2)observation on tumorogenic action with time course, and 3)influences of sexual hormones upon the tumorogenicity. The experimental method consisted in the insertion of beenswaxbased pellets containing 1O% of 4NQO into the ventral lobe of prostate of male Wistar strain rats in their age of 2-3 months. 1)Presence of tumorogenic action: a)Formation of the first tumor could be detected in a rat 230 days after insertion of the pellet. Four other rats developed tumor on the 251st, 253rd. 267th, and 281st days, respectively. Eventually, 5 hout of 9 rats developed tumor, which survived for more than 200 days, The occurrence rate of tumor was, 55.6%. It was concluded on the basis of the above results that 4NQO has tumorogenicity on the prostate of rats.
社団法人日本泌尿器科学会の論文

著者

中西欽也
昭和大学医学部泌尿器科学教室

4-Nitroquinoline 1-Oxideのラット前立腺に対する造腫瘍作用について

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