コレラ菌、ブルセラ菌間の共通抗原に関する研究
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概要
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It was observed that the common antigenic component exists in otherwise unrelated bacteriae, or, between bacteria and other cells. The most remarkable examples are Forssman's heterophile antigen and Weil-Felix reaction. In Weil-Felix reaction, its factor was shown that the alkalistable somatic polysaccharide of Protheus OX strains, refered to as X factor, is common to both Protheus OX 19 and Rickettsia prowazekii. Some workers (Arai, McCullough and others) report the existence of common antigen between Vibrio cholerae and Brucella. The author studied on antigenic components and chemical structure of this common antigen and futher more reviewed the antigenic structure of Vibrio cholerae. The results of experiments were summarized as follows : 1) The author evinced that each of three types of Brucella contains the same two antigens, however the Br. abortus and suis in which the A antigen predominate quantitatively, and the Br. melitensis in which the M antigen predominate, like as a report of Miles and Wilson. On the other hand, Vibrio cholerae have three subtypes, as Inaba, Ogaws and Hikoshima type by the absorption test of agglutinin with OH and O anti-serums. 2) The author observed that the common antigen exists between Vibrio cholerae and Brucella. And called this common antigen as Y factor for the time being. 3) The Y factor was observed as mono-antigenic component, in the three types of Vibrio cholerae and three types of Brucella. And Y factor was entirely different from any other antigenic factor of Vibrio cholerae and Brucella already known. 4) The Y factor existed in somatic substance of Vibrio cholerae as heat stable O antigen. The component of this factor in Brucella was much more than in Vibrio cholerae. 5) The element of Y antigen was observed in somatic polysaccharide fraction of Vibrio cholerae. 6) The action of bacteriolysis to Vibrio cholerae was observed in anti-serum of Brucella as Pfeiffer's reaction and Neisser-Wechsberg phenomenen.
- 九州歯科学会の論文
- 1959-00-00