コラーゲンのハイドロキシアパタイト・チタン複合インプラントへの応用に関する実験的研究
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概要
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The healing process of the gap between bone and a hydroxyapatite-coated titanium implant which was treated with atelocollagen was radiographically and histologically evaluated from 1 month to 6 months. In addition, the effects of this collagen on bone healing were studied by injecting it in the implant-sockets. At 2 weeks after injecting atelocollagen in a socket, granular deposits were often observed in circumference of this collagen which was infiltrated by messenchymal cells. Further, calcein-labeled fluorescence was concentrated in this collagen which contained granular deposits at 1 month. The collagen injected socket demonstrated complete healing with new bone formation and the central portion of socket was not concave at 3 months. These findings suggest that atelocollagen could function principally as a hospitable osteoconductive substrate for bone-forming cells. The healing process of the gap between bone and the hydroxyapatite-coated implant which was inserted by the nontapping method in the mandible was evaluated with and without the treatment with atelocollagen. At 1 month, in the group with the treatment, bone ingrowth often occurred at the screw sites in the portion where cortical bone had been existed. Further, fluorescence micrograph indicated that this collagen might enhance bone healing in this portion. In the groups without the treatment, immature bone had been observed partially in the interface between bone and hydroxyapatite. In contrast, direct bone-implant interface was achieved in the groups with the treatment. At 6 months, the group with the treatment showed histologically about the same findings as the group without the treatment. Direct bone-implant interface has been recognized as an indication of a successful endosseous dental implant. This study suggests that application of atelocollagen to implant might be useful to achieve it.
- 九州歯科学会の論文
- 1991-02-25