乳歯抜歯創の治癒に関する神経組織学的研究
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概要
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A study on the healing of extraction wounds was undertaken regarding the histological changes and fluctuation of distribution of nerve fibers after postoperative intervals of 1, 3, 7, 14, 21 and 35 days. A. The general findings 1. In the healing process following primary teeth extraction, the postoperative 1st and 3rd days are equivalent to the blood clotting stage, 7th-day the granulation tissue stage, 14th-day the trabecula stage, and 21th-day and 35th-day the bone remolding stage. Healing was faster compared with that in the extraction wounds of permanent teeth. 2. The formation of granulation tissue was initiated in a 3-day-old extraction wound. 3. The first evidence of the trabecula formation was already found in a 7-day-old extraction wound. In a wound 14 days old, the whole extraction wound was filled with the trabecula. 4. The remodeling of the trabecula started from the surroundings of the trabecula in deep layers and the extensive absence of the trabecula was seen in deep layer of extraction wound of the 21-day-old, which was thought to be related to the development of succedaneous teeth. 5. The trabecula formed in the extraction wound was resorbed and gradually reduced from the surroundings along with the surrounding original alveolar bone due to the development of succedaneous tooth buds. B. The neurohistological findings 1. In a 1-day-old and a 3-day-old extraction wound, the retrograde degeneration such as swelling of nerve fiber, reduction of stainability, beaded degeneration, and granulation at the cut ends of nerve bundles, was seen. 2. The new nerve fibers from the cut ends were seen in a 7-day-old extraction wound. 3. The new nerve fibers traveled accompanying the new blood vessels and distributed in close relationship with the blood vessels. The nerve bundles in deep layer were thick and the diameter of the nerve fibers was large. As they reached the superficial layer, the bundles became thin and the nerve fibers became slender. 4. In the new fibers, two types were mixed : the nerve fibers extending from the nerve bundles of bone marrow in the original alveolar bone and the ones from the bundles in the dental sac surrounding the succedaneous tooth buds. 5. The nerve fibers distributed in the granulation tissue among the new trabeculae as the nerve bundles of various sizes or single nerve fiber. The nerve fibers increased until 21th postoperative day, but decreased by the 35th postoperative day.
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