妊娠ラットへのビタミン A の過剰投与が胎仔の舌有郭乳頭ならびに味蕾の発育におよぼす影響に関する神経組織学的研究
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The purpose of this study was to investigate the effect of hypervitaminosis A in pregnant rats on the development of circumvallate papillae and taste buds of their fetuses. The experimental materials were divided into three groups treated with one intraperitoneal injection of 75, 000 units, 100, 000 units or 150, 000 units of vitamin A on the 12th day of pregnancy. A neurohistological observation was made from 14th day of fetal life to 4th day after birth in comparison with the control group. 1. The development of circumvallate papillae was delayed with the increase of administration of vitamin A. The formation of sulcus was observed on the 16th day of fetal life in the control group, while it was observed immediately after birth in the 150, 000 unit group. 2. The vacuolation of epithelial cells in the epithelium of circumvallate papillae was seen on the 20th day of fetal life in 100, 000 unit and 150, 000 unit groups. The arrangement of epithelial cells was generally irregular and keratinization was delayed as compared with that of control group. 3. Increase in, dilatation of and bleeding from thin blood vessels in the connective tissue within the circumvallate papillae and around the sulcus were observed with the increase of administration. 4. The development of taste buds was seen on the 2nd day after birth in the 75, 000 unit group as in control group, but its development was slightly inferior. In the 100, 000 unit group the neoblastic cells of the taste buds were observed on the 4th day after birth. 5. The distribution of nerve fibers in the papillae became scanty with the increase of administration and the nerve fibers became smaller. 6. The neoblastic cells of the taste buds arose from the direct contact of nerve fibers with epithelial basal cell layers and the nerve fibers invading into the taste buds increased with the development of the taste buds. However, the nerve fibers distributed to the taste buds were scarce in the hypervitaminosis A group as compared with that in control group and its distribution decreased with the increase of administration.
- 九州歯科学会の論文
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- 妊娠ラットへのビタミン A の過剰投与が胎仔の舌有郭乳頭ならびに味蕾の発育におよぼす影響に関する神経組織学的研究