家兎歯肉癌(VX2 癌)の下顎骨侵襲に関する実験的研究

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In the oral cavity, malignant neoplasms including cancer in the early stage have been known to invade the surrounding soft tissue and jaw bones. However, the mode of invasion varies because of histological structural difference among the gingiva, tongue, cheeks and jaw bones in addition to anatomical complexity of the oral cavity. When the mandible is or is suspected to be invaded by a gingival cancer, wide mandiblectomy is desirable. However, post-operative functional and cosmetic impairment will be great. Therefore, it is most important to have a sufficient knowledge of extent and degree of the invasion by gingival cancers in order to plan optimum surgical limits which at the same time check the foregoing impairment at minimum. A histopathological investigation therefore was made of the extent and degree of mandibular invasion by transplanting VX2 carcinoma into the mandibular gingiva of normal domestic rabbits. The results were as follows : 1. VX2 carcinoma transplanted into the mandibular gingiva of the domestic rabbits prolifered first of all in the gingiva and then destroyed the periosteum of the underlying cortical bone. As invasion progressed, the cortical bone surface showed lacunar resorption and bone destruction in moth-eaten types in part. These findings increased in extent and degree with time as the tumor mass enlarged. 2. In radiological observation of resorption and destruction of the mandible invaded by VX2 carcinoma, the cortical bone was compressed evenly and resorbed and then destroyed in moth-eaten types. While the cortical bone did not show any abnormal findings radiologically, resorption and destruction histologically were already underway. 3. Along with resorption and destruction of the cortical bone by VX2 carcinoma, resorption of inner wall surface and enlargement of canals were observed in the surrounding Harversian and Volkmann canals. In some of the enlarged Harversian and Volkmann canals, VX2 carcinoma invaded and prolifered, and gradually prolifered into the mandible from the cortical bone. 4. Along with invasion and proliferation of VX2 carcinoma into the mandible, periosteal proliferation and periosteal new bone formation were beginning to be observed in the inferior margin of the mandible. 5. With invasion and proliferation of VX2 carcinoma, periosteal new bone formation was observed in the cases of 15-day after transplantation. However, no specific association with enlargement of the tumor mass was found. The formation was presumed to be reactive bone repair.
九州歯科学会の論文
1986-02-25

著者

中尾元彦
九州歯科大学口腔外科学第2講座

家兎歯肉癌(VX2 癌)の下顎骨侵襲に関する実験的研究

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