咬合性外傷の発現から修復までの病理組織学的ならびに組織化学的研究 : 骨吸収における化学的仲介物質の役割について

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The purpose of this study was to investigate the histopathological and enzyme histochemical changes in the periodontal tissues at the bifurcation which the occlusal trauma elicited in rat molars. In addition, the cases administered with the indomethacin which was one of the inhibitors of the prostaglandin biosynthesis were investigated. The following results were obtained. 1. By the injury, the periodontal space narrowed, the periodontal membrane caused decrease and disappearance of the cell ingredients, and partial hyalinization and necrosis occurred. On the other hand, the undermining resorption became active from the bone marrow side about 3 days after operation, the periodontal space was enlarged, and fibroblasts and capillaries increased in the periodontal membrane. The repairing of the periodontal tissue became active from 1 week and in 3 weeks it resembled that in the preoperative period. 2. In the fibrous ingredients of the periodontal membrane, the occlusal trauma elicited decrease and irregular arrangement of collagen fibers, and also decrease, swelling, lowering of staining, and irregular arrangement of oxytalan fibers. As the periodontal tissue was repaired, thin argyrophilic fibers increased from the marrow side and grew up to be meshy collagen fibers, and then the collagen fibers formed bundles and adhered to the cement and the alveolar bone, and at last they were restored to the periodontal membrane in the preoperative period. As oxytalan fibers were repaired, they regenerated, thickened and showed the regular arrangement and good staining. 3. In ALP, the activity was seen totally in the periodontal membrane and specially intensely around the alveolar bone. The activity decreased in the periodontal membrane which was depressed by the occlusal trauma. But its activity became intense again as the repairing progressed. In ACP, the activity was generally weak in the periodontal membrane. It was further decreased in the periodontal membrane which was depressed by the occlusal trauma. But intense activity was shown in osteoclasts and in the periapical area of the undermining resorption area. When the periodontal membrane began to be repaired in a week after operation, the activity decreased totally. But the activity was seen in fibroblasts, osteocytes, osteoblasts and cementoblasts. In LDH, the activity was generally weak, but intense activity was shown in cementoblasts and osteoblasts. The activity decreased in the periodontal membrane which was depressed by the occlusal trauma. The osteoclasts in the undermining resorption area showed intense activity and the fibroblasts in the periapical area showed increased activity. In a week after operation, the activity increased in osteoblasts and cementoblasts. 4. As compared with the nonindomethacin treated rat group, the indomethacin treated rat group showed decrease in the number and morphologic changes in osteoclasts. This suggested that the indomethacin inhibited the biosynthesis of the prostaglandin which was related to the appearance of the osteoclasts. As the result, it was postulated that the indomethacin depressed the bone resorption which played an important role in the destruction of the periodontal tissue in the periodontal disease.
九州歯科学会の論文
1985-02-25

咬合性外傷の発現から修復までの病理組織学的ならびに組織化学的研究 : 骨吸収における化学的仲介物質の役割について

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