ベンゾジアゼピン受容体作動性抗不安薬の青斑核-大脳皮質前頭前野ノルエピネフリン神経系への作用

概要

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In this study the effects of benzodiazepine receptor agonistic anxiolytics were examined on the locus coeruleus (LC)-prefrontal cortex (PFC) norepinephrine neurons of freely moving rats, and on stress-induced increase in extracellular norepinephrine in the PFC. While benzodiazepine receptor agonistic anxiolytics were infused via a microdialysis probe in the vicinity of the right LC, the extracellular content of norepinephrine was recorded in the ipsilateral PFC with another microdialysis probe. The differential types of benzodiazepine receptor agonistic anxiolytics midazolam (benzodiazepine receptor full agonist, 10^<-4>M and 5×10^<-4>M) and Y-23684 (benzodiazepine receptor partial agonist, 10^<-4>M and 5×10^<-4>M) were used. While infusions of Y-23684 (5×10^<-4>M) decreased extracelllar norepinephrine in the PFC, midazolam was not effective for the basal values. Next, rats were gently handled for 10 min during infusion of these drugs. The infusion of midazolam (5×10^<-4>M) and Y-23684 (5×10^<-4>M) inhibited the handling stress-induced increase in extracellular norepinephrine in the PFC. Benzodiazepine receptor antagonist flumazenil (10^<-4>M) attenuated these effects. These indicate that benzodiazepine receptors agonistic anxiolytics play a major role in suppressing stress responses, by acting via benzodiazepine receptors.
九州歯科学会の論文
2001-10-25