虚弱骨に対するカルシウム食療法に関する X 線的, 光顕的および超微形態的研究 : 下顎頭の変化
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Calcium-deficient food was given to three-week old Wistar rats and bone debility was induced in them. Then, standard food and mixed food (standard food : cattle bone powder=3 : 3) were used and an investigation was made on the effect of calcium food treatment on the growth of cartilage of the mandibular condyle, bone remodeling, and bone reconstruction. The results were as follows : 1. Histopathological findings Chondrocytes of the mandibular condyle in the control group were regularly arranged and divided into five zones. Chondrocytes of the mandibular condyle in the calcium-deficient food group were arranged thick. Chondrocytes in the proliferic zone showed decreased in cells and an abnormal increase in chondrocytec in the hypertrophic zone. Calcified matrix surrounding hypertrohic chondrocytes decreased and the findings of invasion of calcified matrix also decreased. Young bones found in the subchondral bone formation zone were markedly decreased and disappeared, and most trabeculae were low calcified layers. In the calcium-deficient food + standard food group, findings of invasion of calcified matrix surrounding hypertrophic chondrocytes, of chondroclasts, and of calcified matrix increased. In the subchondra bone formation zone, young bones increased and the trabeculae below also showed an increasing tendency, but low calcified images of osseous layers were still seen. The calcium-deficient food + high calcium food group, as compared with the calcium-deficient food + standard food group, showed an increase in hypertrophic chondrocytes. The calcified matrix surrounding hypertrohic chondrocytes decreasd, and findings of invasion of calcified matrix by chondroclasts also decreased. In subchondra bone formation zone, the trabeculae below decreased in part, and low calcified layers increased. 2. Scanning electron microscope findings The mandibular condyle in the control group were clear in form and thick bone matrices were found. In the calcium-deficient food group, chondrocyte layers became wider and lacune of chondrocytes with distinct and indistinct demarcation mingled. Trabeculae showed marked increase in resorption surfces, and decrease in trabeculae was clear. In the calcium-deficient food + standard food group, demarcation of lacunae of chondrocytes was about clear. Observation of the bone matrix showed networks of collagen fibrills on dense collagen fibrillsrunning in a given direction on the surface of the bone matrix. In the calcium-deficient food + high calcium food group, as compared with the calcium-deficient food + standard food group, chondrocyte layers were wide and chondrification (chondritic ossification) continuing toward the inferior direction was restricted. On the basis of the foregoing findings, in the calcium food treatment for debilitated bone, it became clear that bone resoption images decrease and that bone reconstruction by bone remodeling is active in the standard food group as comapred with the high calcium food group.
- 九州歯科学会の論文
- 1994-12-25
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