三叉神経領域の Mononeuropathy に関する実験的研究
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概要
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A method for establishing the trigeminal mononeuropathy model in rats was studied and an immunohistochemical observation was performed for this model. Unanesthetized rats were used for determinating cutaneus hyperalgesia using thermal stimulation of the second division of the trigeminal nerve. Two ligatures were tied loosely around the unilateral infraorbital nerve, and a sham-operation was performed on the contralateral side. The latency of head withdrawal response to noxious radiant heat was measured in these rats. A remarkable decrease in the latency was observed after operations on both sides, and the decrease was more significant on the ipsilateral side compared with contralateral side from the fourth to twelfth postoperative days. These findings, however, were not evoked by sham-operation in the control group. Ipsilateral hyperalgesia induced by the incomplete ligation of the infraorbital nerve indicates the onset of mononeuropathy and the hyperalgesic response in the contralateral side was also affected by the mononeuropathy and not by inflammation induced by the sham-operation. An immunohistochemical study of substanse P (SP), calcitonin gene-related peptide (CGRP), and dynorphin (DYN) in the trigeminal subnucleus caudalis (TNC) was performed on the fourth and eighth postoperative days. None of the cases showed any remarkable changes in staining density for SP and DYN, though several cases showed an unmistakable increase of CGRP immunoreactivity at both points in the ipsilateral laminae I-II a of TNC in the ligation group. These findings are different from those in the sciatic mononeuropathy model. CGRP clearly plays an important part in the mechanism of the trigeminal mononeuropathy.
- 九州歯科学会の論文
- 1993-02-25