VX2 舌癌の領域リンパ節転移に関する実験的研究

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In treatment of cancer, controling primary lesion and preventing recurrence are of course intended. At the same time, coping with metastatic leision is an important factor that affects improving treatment results and quality of life. Having a grasp of mode of lymphatic metastasis of oral cancer therefore is an extreamly important factor for selection of treatment method and for treatment results. The author therefore transplanted VX2 carcinoma into the tongue of domestic rabbits and investigated the state of metastasis to the regional lymph node. The results were as follows : 1. VX2 carcinoma transplanted into the tongue of domestic rabbits implanted in the muscle layer at the lingual margin on the transplanted side and infiltrated and proliferated into the surrounding muscle layers by the week, resembling small cellulae or cord-like form. In the cases 4 weeks after transplantation, the carcinoma infiltrated and proliferated across the median line into the opposite side. 2. In the cases 2 weeks after transplantation, VX2 carcinoma cells destroyed venous walls and penetrated into and grew in the lumina. Penetration into arterious walls was seen from the cases 3 weeks after transplantation. 3. Rate of metastasis to the regional lymph node was 36.5% (35/96 lymph nodes) and the rate increased with growth of the transplanted VX2 carcinoma. In the cases 4 weeks after transplantation, the rate was as high as 64.0% (16/25 lymph nodes). Lymph node metastasis was seen especially from the cases 2 weeks after transplantation where penetration into blood vessels was seen. 4. The rate of lymph node metastasis on the transplantation side was 44.9% (22/49 lymph nodes). Metastasis to the submandibular lymph node was 35.5% (11/31 lymph nodes) and to the cervical lymph node was 61.1% (11/18 lymph nodes). At the same time, the rate of lymph node metastasison the non-transplantation side was 27.7% (13/47 lymph nodes). Metastasis to the submandibular lymph node was 21.4% (6/28 lymph nodes) and to the cervical lymph node was 36.8% (7/19 lymph nodes). Metastasis rate increased by the week and the rate of metastasis to the cervical lymph node on the non-transplantation side especially was high 3 and 4 weeks after transplantation. 5. According to stages of lymph node metastasis by Honma's classification (1982), Stage I was 48.6% (17/35 lymph nodes), Stage II 22.9% (8/35 lymph nodes) and Stage III 28.6% (10/35 lymph nodes). On the non-transplantation side, lymph node metastasis was seen relatively early. 6. Infiltration, growth, and lymph node metastasis of the tongue cancer by VX2 carcinoma transplantation were similar to those of human tongue cancer and are useful as a model for the oral cancers. 7. On the basis of the foregoing results, infiltration and growth of a tumor in the primary lesion are related to metastasis to lymph node and stage, and are thought to be important as factors for prognostic judgement. Metastasis was not only lymphatogenous but also hem-okinetic. These experimental results in addition to clinical findings are useful information in determining the timing of metastasis to the regional lymph node and measures to be taken.
九州歯科学会の論文
1993-02-25

VX2 舌癌の領域リンパ節転移に関する実験的研究

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