実験的骨粗鬆症に対するカルシウムの影響に関する X 線学的ならびに病理組織学的研究 : とくに成熟期の歯槽骨
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Osteoporosis was induced experimentally in male rats of Wistar strain. These rats were then given a standard solid diet (control group) and a calcium-enriched diet (experimental group) and effect of diet on facilitation of formation of bone tissue was investigated. The results were as follows : 1. Radiological, light microscopic, and photo-densitometric findings showed higher bone density of the alveolar bone and tibia in the experimental group than in the control group. 2. Analysis of Ca and P on the X-ray microanalyzer showed high values of Ca in the experimental group with 1% significance level each week. At 10 weeks, high values of P were shown for the experimental group with 5% significance level. The experimental group showed higher relative Ca quantitative ratios (Ca/[Ca]c) and relative P quantitative ratios (P/[P]c) than the control group. 3. In histopatholgical findings, CMR images showed increase in the amount of bone, Haversian canals, and bone lacunae. General tissue findings showed thickening of osseous layers, decrease in resorption findings, regularity of Sharpey's fibers, increase in Haversian canals and bone lacunae. The tibia also showed similar findings. 4. Hemological findings showed high AL-P values at 8 weeks and high LDH and GPT values at 9 weeks. On the basis of the foregoing findings, continuous administration of a calcium-enriched diet on a long-term basis for debilitative alveolar bone and tibia proved to facilitate bone formation (by accelerating formation of bone tissue).
- 九州歯科学会の論文
- 1990-06-25
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- 実験的骨粗鬆症に対するカルシウムの影響に関する X 線学的ならびに病理組織学的研究 : とくに成熟期の歯槽骨