口腔領域各種疾患における組織内活性酸素消去系酵素の活性値に関する研究

概要

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Specific activities of free radical scavenger enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase were assayed with oral tissues of patients with oral diseases. The tissues were classified pathologically into 10 different groups ; maxillary sinusitis (n=38), radicular cyst (n=18), follicular dental cyst (n=6), odontogenic keratocyst (n=6), postoperative maxillary cyst (n=8), fibroma (n=3), epulis granulomatosa (n=5), pleomorphic adenoma (n=4), ameloblastoma (n=4) and gum cancer (squamous cell carcinoma) (n=38). Healthy gum (n=38) was used as control. Activities of free radical scavenger enzymes in oral tissues were found to vary among oral diseases. 1. Total SOD (Mn-SOD+Cu・Zn-SOD) activities were high in fiber tissue enriched diseases such as fibroma and low in maxillary sinusitis and gum cancer. 2. Cu・Zn-SOD activities were low in maxillary sinusitis and radicular cyst as well as in gum cancer. 3. GSH-Px activities were high in maxillary sinusitis, radicular cyst, fibroma, epulis and gum cancer. 4. Catalase activities were high in maxillary sinusitis and odontogenic keratocyst, and low in epulis.
1990-02-25