Bleomycin, Mitomycin C と Vitamin A との併用による家兎耳下腺への影響に関する実験的研究

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Chemotherapy for oral cancer is an important treatment method next to surgical therapy and radiotherapy. It is therefore important to have a grasp of the cytocidal effect of anticancer agents on normal cells and tissues from the viewpoint of tumor-host-drug relationship. In chemotherapy, several anticancer agents have been combined in use or combined with non-antitumor agents to increase antitumor effect and to minimize side effects. Of these non-antitumor agents, vitamin A has lysosome stabilizing effect and membrane active effect, and has been reported to increase antitumor effect when combined in use with anticancer agents. While vitamin A increases antitumor effect, its influence on normal tissues is also expected. Therefore, Bleomycin (BLM) and Mitomycin C (MMC), frequently used in chemotherapy for oral cancer, were combined with vitamin A (V・A) and the effect of these combinations on the parotid gland of domestic rabbits was investigated histopathologically. The results were as follows : 1. In the terminal portion, both BLM-V・A and MMC-V・A combined administration cases showed marked atrophy and destruction of acinous cells, and pyknosis and deformation of nuclei, as compared with the cases of administration of BLM or MMC only. Between scattered acinous cells, stagnation and hyperemia were observed. Along with these regressive changes, PAS stainability, PAS positive substance and A・M stainable substance were considerably decreased. These findings were seen first in the peripheral part of the gland, and gradually passed to the middle of the gland with increase in the number of administration. In the 15 dose cases especially, these findings were observed markedly in the whole gland. 2. In the intercalated duct and striated duct, both BLM-V・A and MMC-V・A combined administration cases showed marked atrophy of epithelial cells of the ducts, and pyknosis and deformation of nuclei, in comparison with the cases of administration of BLM or MMC only. In the surrounding capillary vessels, dilation due to stagnation and hyperemia was observed. These findings increased in severity as the number of administration increased. 3. In the excretory duct, hardly any morphological changes were seen as compared with controls and the cases of administration of BLM or MMC only. 4. Regressive changes attributable to the combined use of vitamin A with BLM and with MMC were clearly recognized. However, no specific histological changes for medicine could be found in the experimental series. 5. On the basis of the foregoing experimental findings, both BLM and MMC caused in the parotid gland of domestic rabbits not only morphological changes but also functional changes in synthesis of secretory substance and excretion. The combined use with vitamin A in addition to its pharmacological peculiarity was thought to aid and promote regressive changes and reduction of function.
九州歯科学会の論文
1987-12-25

Bleomycin, Mitomycin C と Vitamin A との併用による家兎耳下腺への影響に関する実験的研究

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