雌雄ラット耳下腺のメトキサミンおよびピロカルピン刺激唾液成分の加齢的変化について
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概要
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Saliva secreted in response to α_1-adrenergic and cholinergic receptor agonists such as methoxamine (Methox), α-methylnoradrenaline, and pilocarpine (Pilo) was collected from the cannulated ducts of parotid glands of both male and female rats from 4 to 10 weeks and 3.5, 8, and 15 months of age. It was analyzed for volume, for the concentrations of protein, potassium, calcium, inorganic phosphate, and amino acid residues, and for the types of proteins, amylase activity and isozymes. After the collection of saliva, the parotid glands were carefully removed and weighed. The wet weights of the glands increased substantially up to 8 weeks of age and then reached almost plateau values and finally tended to decrease at 15 months of age in both sexes. The salivary volumes secreted in response to Methox and Pilo were positively correlated with the parotid gland weights in both sexes. The concentrations of protein, potassium, and inorganic phosphate were inversely related to the salivary flow rates only at relatively low rates of flow in contrast that the amylase activity was positively correlated with the concentration of protein independent of the nature of the stimulus, age, and sex. In the α_1-adrenoceptor stimulation, the amylase activity was positively correlated with the concentration of calcium independent of age and sex. The types of protein, amino acid residues, and amylase isozymes did not show a great deal of differences at least qualitatively independent of the nature of the stimulus, age, and sex from 4 weeks up to 15 months of age. However, in parotid saliva of several rats at 8 and 15 months of age, the abnormal proteins were electrophoretically observed independent of the nature of the stimulus and sex. The relatively low molecular proteins in parotid saliva were selectively adhered to the resin plate regardless of the types of plate without polishing procedures in only dry states. Thus, it was conclusively elucidated that the secretory function of both α_1-adrenergic and cholinergic receptors in the parotid glands of rats was complete at early stages and intact up to 15 months of age although some exceptions were observed in the protein secretion at elderly stages.
- 九州歯科学会の論文
- 1987-06-25
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