活性型ビタミン D (1α-OH-D_3) の成長期顎骨に及ぼす影響に関する実験的研究 : とくに下顎頭の変化

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• Five-week-old rats of Wistar strain were given 1α-OH-D_3, an analogue of an active type vitamin D_3, 0.1μg/kg, 3 times a week, and its effect on the mandibular condyle, tibia epiphysis, and tibia metaphysis was examined radiologically and histopathologically. The results were as follows : I. Radiological findings 1). The compact osseous layer seen along the periphery of the mandibular condyle and the tibia epiphysis were hick from one week after the experiment, and bone trabeculae increased in number and were running compactly. The trabeculae of the mandibular condyle became narrower from two weeks after the experiment, while the trabeculae of the tibia epiphysis became narrows from three weeks after the experiment. 2) The bone trabeculae in the tibia metaphysis inceased in number and were running compactly from one week after the experiment. From three weeks after the experiment, the trabeculae became narrower. II. Histopathological findings 1). In the mandibular condyle one week after the experiment, increase in proliferative chondrocytes and hypertrophic chondrocytes made the cartilage layer thicker, and chondroclasts and erosion of calcified cartilage matrix decreased. Two and three weeks after the experiment, decrease in hypertrophic chondrocytes made the cartilage layer thinner, and chondroclassts and erosion of calcified caltilage matrix increased. Four weeks after the experiment, increase in hypertrophic chondrocytes made the cartilage layer thicker again, and chondroclats and erosion of clacified cartilage matrix decreased. Subchondral bone formation was always very active. Osteoclasts appeared two weeks after the experiment, and the trabeculage narrowed but were not seen four weeks after the expriment. 2) In the tibia epiphysis from one to three weeks after the experiment, decreased in hypertrophic chondrocytes made the cartilage layer thinner, and chondroclasts and erosion of calcified cartilarge matrix increased. Four weeks after the expriment, changes in the cartilarge layer, chondroclastes and erosion of calcified cartilage matrix were not observed. Subchondral bone formation was always very active. Osteoclasts appeares two weeks after the experiment and the trabeculae narrowed. 3) In the tibia metaphysis one week after the experiment, decrease in hypertrophic chondrocytes made the cartilage layer thinner, and increase in hypertrophic erosion of calcified cartilage matrix was observed until three weeks after the start. Intrachondral bone formation was always very active. Osteoclasts appeared two weeks after the experiment, and the trabeculae narrowed. 4) Scanning-electron-microscopically, in the mandibular condyle and tibia epiphysis, calcospherites in the chondrocyte lacunae became sparse with time, but they were dense again in the mandibular condyle four weeks after the experiment. On the basis of the foregoing findings, administration of 1α-OH-D_3 was found to accelerate bone formation in the mandibular condyle, tibia epiphysis, and tibia metaphysis. As for growth of cartilaginous tissue, the mandibular condyle showed more complex changes than the tibia epiphysis or tibia metaphysis. On the basis of changes in apperance of osteoclasts, the mandibular condyle showed better bone formation.

• 1987-06-25

著者

• 木下 孝昭

  九州歯科大学小児歯科学講座

関連論文

• 活性型ビタミン D(1α-OH-D_3) の成長期顎骨に及ぼす影響に関する実験的研究 : とくに下顎頭の変化 : 主論文の要旨
• 活性型ビタミン D (1α-OH-D_3) の成長期顎骨に及ぼす影響に関する実験的研究 : とくに下顎頭の変化

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