上顎側方拡大後の正中口蓋縫合の修復機序に関する組織化学的研究
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概要
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The present study was performed to histopathologically and histochemically examine the process of new bone formation in the midpalatal suture following the maxillary expansion in the rat. The results were as follows : 1. Histopathological findings. New bone formation of sutural space following maxillary expansion gradually proceeded from the 1st day after the expansion. Two weeks after the expansion, the bone formation of the suture area increased and the midpalatal suture was narrow. 2. Histochemical findings. 1) In ALP, the activity of the bone wall margin was stronger than that of the control from the beginning of retention to the 5th day. But, 2 weeks after the expansion, that activity gradually decreased. The activity of fibroblasts, collagen fibers and osteocytes was not observed through out the experimental stage. 2) In ACP, the activity of the bone wall osteoblasts was as strong as that of the control until the 3rd day after the expansion. After the 5th day of retention, the activity decreased. The activity of the fibroblasts on the 3rd day was stronger than that of the control. But, after the 5th day of retention, the activity gradually decreased. The immature osteocytes in the newly formed bone indicated high activity from the 1st day to 1 week after the expansion. But 2 weeks after the expansion, that activity remarkably decreased. Fibrous connective tissue showed almost the same low activity as the control. 3) In LDH, the activity of osteoblasts, fibroblasts and osteocytes was strongly observed in the beginning of retention period. In the fibrous connective tissue, high activity was also observed. Subsequently, the activity of LDH gradually increased until the 5th day after the expansion. But from 1 to 2 weeks after, the activity was low as compared with the other experimental groups. 3. From these points of view, at the orthopedically expanded midpalatal suture osteogenesis occurred from the bone wall and reconstruction progressed. In light of these facts, it was considered that ALP, ACP and LDH were very important emzyme for osteogenesis.
- 九州歯科学会の論文
- 1987-02-25