イヌの舌乳頭への放射線障害に関する実験的研究
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概要
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Disturbance of the sense of taste is known to be caused by radiation therapy for tumors in the head and neck region. For the purpose of investigation of changes of the lingual papillae pathohistologically, X-ray irradiation to the lingual dorsal membrane of the tongue was experimented and light microscopic and scanning electron microscopic observations were made. Nineteen young dogs, 3∿5 months old, were used for this experiment. Single dose of 1, 000_R was given in three irradiations at intervals of three days. Observations were made on the 1st, 3rd, 5th, 9th, 15th, 35th, and 60th days. The main findings were as follows. 1. The dogs became slow in motion, lost appetite, and left a third of their feed beginning on the 5th day after irradiation. From the 8th to 9th days, eye mucus and secretion from the eyes increased and appearance of weakness increased. Beginning on the 15th day, signs of recovery were observed. 2. The cases on the 5th day showed marked degeneration of yellowish-brown color of the lingual mucous membrane in the region closest to the irradiation tube. 3. Microscopically, the degenerated region was coincident with the region of erosion formation in which neither the lingual papillae nor epithelial layers were observed. Lamina propria of the mucous membrane where infiltration of inflammatory cells was marked was exposed directly. 4. Scanning electron microscopic observation of this erosion region showed a mixed finding of innumerable inflammatory cell group that migrated to the surface of the lamina propria and debris of the epithelial layer. 5. In the lamina propria of the mucous membrane of this region, connective tissue fibers were disorderly arranged and most blood vessels were congested and expanded. Muscular fiber groups extending to this layer were atrophied and striated structures were unclear. 6. The filiform and fungiform papillae in the ordinary mucous membrane neighboring to the degenerated one maintained their forms. However, erosion in part of the epithelial layer and edema in places including the lamina propria were seen. Scanning electron microscopically, both papillae changed some in morphology and their surfaces were rough, and countless microorganism and parasite-like structures aggregated together densely. The taste buds of fungiform papillae decreased in number, and showed atrophy, decrease, and vacuolar degeneration of their cells (light or sustentacular cells). 7. In the cases on the 5th day and those on the 15th day, the discolored region of mucous membrane was considerably limited beginning with the cases on the 9th day. In the cases on the 15th day, limitation was brought about by restoration of epithelium. Inflammation of adjacent healthy colored region was slight. 8. The shorter the interval after irradiation, the lighter was disturbanced. In the cases of one day after irradiation, especially, any region appeared about the same as that of controls. 9. As epithelium of the mucous membrane recovered and prolifered in the cases on the 15th day and thereafter, the number of taste buds and of taste bud cells was restored. However, atrophy of cells still continued and cell arrangements were irregular. Even in the cases on the 35th day after irradiation infiltration of inflammatory cells was seen in some taste buds and complete restoration to the normal image was seen only after 60 days.
- 九州歯科学会の論文
- 1986-12-25