三叉神経節細胞の加齢的変化に関する研究
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概要
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Morphological changes of nerve cells with advancing age, especially accumulation of lipofuscin granules, were investigated by histochemical and autofluorescent methods with the use of trigeminal ganglion of rats, ranging in age from one week to 18 months. The results were as follows : 1. At one week of age there were some immature cells of large nucleocytoplasmic ratio. The immature cells decreased at four weeks of age and the average size of nerve cells remained fairly constant during later life. 2. The degenerative change of nerve cells such as atrophy and residual nodules were sometimes found in the old age group. But marked decrease and unusual distribution of Nissl bodies was not found and the number of nerve cells did not change significantly with age. 3. PAS positive granules were found at four weeks of age and Sudan Black B positive granules were found at eight weeks of age. The percentage of nerve cells containing PAS positive and Sudan Black B positive granules increased progressively with age and a progressive increase in the percentage of cytoplasmic areas occupied by PAS positive and Sudan Black B positive granules was also observed with age. 4. The distributions in the cytoplasm of PAS positive and Sudan Black B positive granules were shown variously. In the young age group PAS positive and Sudan Black B positive granules were distributed diffusely in the cytoplasm in fine granules. As the aging process advanced, the coarse granules of PAS positive and Sudan Black B positive were accumulated more and more at the perinuclear position. 5. The autofluorescent granules were first seen at the age of six months. The granules exhibited light yellow fluorescence and intense bright yellow granules increased with advancing age. 6. By PAS reaction, Sudan Black B reaction and autofluorescent methods, the location of lipofuscin granules almost corresponded, though the time when they first appeared was different. 7. In the trigeminal ganglion an increase of lipofuscin granules accumulation was revealed. The presence of lipofuscin granules accumulation was revealed. The presence of lipofuscion granules occupying most of the cytoplasmic area in nerve cells may probably affect physiological and metabolic functions of nerve cells.
- 九州歯科学会の論文
- 1986-12-25