凍結温度の変化が舌下神経線維に及ぼす影響に関する実験的研究

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A neuro-pathohistological study was made with use of 83 Wistar rats on the relation between the temperature and the nerve tissue injury with cryosurgery for N. hypoglossus. The N. hypoglossus were exposed at the proximal side and frozen at various temperatures from -10℃ to -70℃ for 90 seconds. The results were as follows : 1. On first day after freezing, the bundle of nerve fibers in the tongue suffered degeneration at all freezing temperatures without exception. Degeneration progressed in order of expansion, fragmentation and disappearance, and proceeded in the direction of the apex region from the radical region of the tongue. 2. The area of degeneration of the nerve tissues corresponded with the distribution of the frozen nerve bundle from the radical region to the apex region of the tongue at all freezing temperatures with no exception. 3. Injury from freezing nerve bundle showed remarkable difference with -30℃ as the demarcation : slight at higher temperatures and severe at lower temperatures. 4. The degenerative finding in the distal nerve remained until 14th day but disappeared at all freezing temperatures without exception by 20th day. 5. Regeneration of nerve bundle started with proliferation of Schwann cells in the same area where the degenerated nerve tissues disappeared. Minute nerve fibers appeared next among the proliferated Schwann cells, and joining of these minute fibers followed. Regeneration advanced from the radical region toward the apex region of the tongue. 6. Schwann cells appeared first on 5th day in the radical region at all freezing temperatures without exception. Their appearance was remarkable in the group of temperatures higher than -30℃ but slight in the group of lower temperatures. 7. In the radical region, the minute nerve fivers appeared on 5th day in the group of -10℃, and on 7th day in the other groups with the exception of the group of -70℃. 8. On 20th day, joining of the minute nerve fibers reached the apex region from the radical region of the tongue, and the nerve distribution was about completed with formation of bundle with the exception of -70℃, group. 9. In the group of -70℃, Schwann cells still remained on 30th day among the nerve fibers at the apex region. As stated above, the practical freezing temperature which affects the nerve tissues is -10℃. At the temperatures lower than -30℃, the effect is severer but the restoration of nerve tissues is very active and accelerated. The course of change is the same as in surgical resection but restoration is much faster.
九州歯科学会の論文
1985-10-25

著者

田中二郎
九州歯科大学口腔外科学第1講座

凍結温度の変化が舌下神経線維に及ぼす影響に関する実験的研究

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