発育初期におけるラット顎関節の酵素組織化学的研究

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A histological and histochemical study was undertaken to clear the rat temporomandibular joint in the early developmental stage. The following results were obtained. I. General histological finding 1. In rat, the early formation of the articular disc was seen at 18 days fetus. And at 20 days fetus, the early forms of the mandibular fossa and head were regulated, and the membraneous ossification was seen in the mandibular head at immediately after birth, and an increase of the blood vessels was observed in the peripheral area of the base of the articular disc from about 12 days after birth. II. Enzyme histochemical finding 1. In alkaline phosphatase, the activity area was seen continuously between the zygomatic process and the temporal bone at 18 days fetus, and in the developmental stage of the mandibular fossa the activity area was seen in the circumference of the bone matrix and the fibrous connective tissue on the surface of the mandibular fossa. However, the articular disc did not showed the activity. In the mandibular head, the high activity was seen in the mature chondrocytes, the enchondral ossification and the membraneous ossification areas. 2. In acid phosphatase, the mandibular fossa showed the high activity in the central bone addition area and the articular disc showed the significant high activity in the area facing to the upper and lower articular spaces at 20 days after birth. The mandibular head showed an increase of activity with the maturation of the chondrocytes, and activity in the enchondral ossification area increased with passage of time. The activity higher than moderate one was seen in the circumference of the membraneous ossification area. 3. In adenosine triphoshatase, the high activity was seen in the circumference of the bone matrix of the articular fossa, especially in the area where its central bone addition was excellent. The high activity was seen in the articular disc and in the circumference of the basal area. In the mandibular head, the activity increased in the part of its surface with maturation of the chondrocytes. And the activity was seen in the area only where the enchondral ossification had just occured. 4. In thiamine pyrophosphatase, the area forming the bone matrix of the articular fossa and enchondral ossification area in the mandibular head showed the high activity. The articular disc showed the low activity in the areas facing to the upper and lower articular spaces. 5. In lactate dehydrogenase, the articular fossa showed the activity in the osteoblasts and osteocytes in the central bone addition area. The articular disc showed the clear activity, and high activity area existed in the lower articular space. The mandibular head increased the activity with the maturation of the chondrocytes, and the enchondral ossification area showed the high activity in the circumference of the grown bone trabeculae. 6. In succinate dehydrogenase, the articular fossa showed the activity in the osteoblasts and osteocytes. The low activity was seen in the articular disc and the fibrous connective tissue layer on the surface of the mandibular head, but little activity was seen in the chondrosis layer. 7. In isocitrate dehydrogenase, the osteoblasts and osteocytes of the articular fossa showed the activity, and the articular disc showed it in the layer contacting with the upper and lower articular spaces. The chondrocyte of the mandibular head increased the activity with its maturation, and significant high activity was seen in the membraneous ossification and enchondral ossification
九州歯科学会の論文
1984-04-25

著者

林慶祐
福岡歯科大学口腔病理学講座

発育初期におけるラット顎関節の酵素組織化学的研究

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