制癌剤の舌創傷治癒におよぼす影響に関する実験的研究
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概要
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Chemotherapy for oral cancer is without doubt an important treatment method along with surgery and radiotherapy. Surgery however faces some limitations because of anatomical considerations. A speedy healing, functionally and morphologically, of surgical wounds in the postoperative period is also desirable. For prevention of local recurrence and metastasis, an extended administration of anticancer agents is necessary. A histopathological investigation therefore has been made of the effect of agents on healing process of the wounds experimentally made in the tongue of domestic rabbits. For the experimence, Bleomycin and Mitomycin C were used and Prednisolon was selected for contrast. Each agent was administered in high-dose and in low-dose by group. The results were as follows : 1. In the group treated with Bleomycin in high-dose (3.0mg/kg/day), proliferation and maturing of fibroblasts, granulation tissues and epithelial cells were retarded in each group. Maturing of epithelial cells in particular was retarded. Retardation increased with an increase in the number of administration and the amount of dosage. These findings were more evident in the high-dose groups than in the low-dose groups (1.5mg/kg/day). 2. In the high-dose Mytomycin C groups (0.5mg/kg/day), proliferation and maturing of fibroblasts and granulation tissues were retarded. Epithelial cells however were not retarded to the same extent. Infiltration of inflammatory cells was less in comparison with the groups treated with the other agents. These findings were more evident with an increase in the number of administration and the amount of dosage, and in the high-dose groups than in the low-dose groups (0.25mg/kg/day). 3. In the high-dose Prednisolon groups (5.0mg/kg/day), proliferation and maturing of fibroblasts, granulation tissues, and epithelial cells were retarded. Retardation was more evident with an increase in the number of administration and the amount of dosage and in the high-dose groups than in the low-dose groups (2.5mg/kg/day). 4. Bleomycin, Mitomycin C and Prednisolon had a retarding effect on healing of the tongue wounds. Mytomycin C and Prednisolon had a strong retarding effect on proliferation and maturing of fibroblasts and granulation tissue, and Bleomycin on those of epithelial cells.
- 九州歯科学会の論文
- 1981-03-25
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関連論文
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- 制癌剤の舌創傷治癒におよぼす影響に関する実験的研究 : 主論文の要旨
- 制癌剤の舌創傷治癒におよぼす影響に関する実験的研究
- 口腔癌および口腔領域各種疾患における血清糖蛋白についての検討