VX_2 癌移植家兎における血漿および諸組織中の亜鉛・銅量に関する研究

概要

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Zinc and copper levels in rabbit bearing VX_2 carcinoma were determined with the flameless atomic absorption spectrophotometer. The levels in plasma, tumor, femur muscle surrounding tumor, non-planted femur muscle, liver, spleen and pancreas were surveyed on the third day after implantation and every week for six weeks. These data rearranged into five groups (stage 0-IV) along with the growth of tumor. The plasma zinc decreased in stage II and III but the copper increased. Then the Cu/Zn ratio was high level as in malignant tumor patients. The zinc levels in tumor in stage II, III and IV were higher than those in stage 0. The zinc in the surrounding muscle of the VX_2 carcinoma decreased in stage I and III. Its levels in stage II and III were lower than those of the control opposite muscle. The zinc concentration in tumor could be accumulated via surrounding muscle because of its level in the other side was almost the same. The zinc and copper in liver increased in stage II, III and IV and the Cu/Zn ratio decreased. The levels in pancreas showed no changes between the control and the tumor groups, but the Cu/Zn ratio in stage II and III were significantly higher than those in the stage 0. The neoplastic liver and pancreas are antagonized under the biochemical changing from the point of Cu/Zn ratio. These results described above justly offer further investigations for clinical surveys in neoplastic disease.
九州歯科学会の論文
1979-03-31