Vx2 癌移植による家兎舌癌の病理組織学的研究

概要

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Carcinoma of the tongue was produced by implantation of Vx2 carcinoma in the tongue of domestic rabbits. The mode of proliferation of Vx2 carcinoma, the changes with the proliferation in the tongue, and vascular invasion by the cancer cells were investigated on the seventh, tenth, fourteenth, and twenty-first day after implantation. The results were as follows : 1. The cancer in the tongue enlarged with an increase in the elapsed time after implantation and proliferated infiltratively in the tongue. The vertical muscle bundles in the midline, however, showed some resistance to infiltration by the cancer cells into the non-implanted side. 2. An edema was observed in the tongue anterior to the carcinoma with the enlargement. 3. The edema was caused by hydrops and the vascular invasion by the cancer cells were deemed to be related to the occurrence of hydrops. 4. The vascular invasion by the cancer cells was observed in all the subjects between the seventh and fourteenth day. 5. The sites of the vascular invasion were almost entirely limited to the venous system. Cancer cells were observed to proliferate along the long axis in the lumens of the veins. 6. Capillary invasion was also observed, although to a lesser degree compared with the venous system. 7. The majority of vascular invasions were observed with formation of an intravascular thrombus.
九州歯科学会の論文
1978-09-30