9, 10-Dimethyl-1, 2-Benzanthracene による家兎上顎癌形成過程の病理組織学的研究
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In order to clarify so called central cancer of the maxillar whigh has the highest rate of incidence clinically, importance of basic researches of the maxillary carcinoma is intensified. As a basic research, Nagai of our department surgically placed by his own method 9, 10-Dimethyl-1, 2-Benzanthracene (DMBA) into the maxillary sinus of domestic rabbits and made observations for about 14 months. He reported a success in inducing tumors similar to squamous cell carcinoma found most frequent histopathologically in human. The report on the experimental carcinogenesis contains various findings as guide to be applied to clinical work for human maxillary carcinoma. The report however does not contain any description in detail of the process of carcinogenesis from normal mucous memebrane of the maxillary sinus composed of multi-serial ciliated cylindrical epithelium to sqamous cell carcinoma. The author of this report undertook and experiment to induce tumors in the maxillary sinus of domestic rabbits by a similar method and made a histopathological investigation of the changes in the process of formation. The results obtained were as follows : 1. Bees wax pellets containing 10 mg of DMBA (concentration 25%) were prepared and placed surgically into the maxillary sinus of the rabbits. 2. The experiment animals were killed in 3rd, 6th, 9th, and 12th month and were examined for the extent of formation. Confirmation of squamous cell carcinoma was made in the 12th month in 2 of the 7 cases which were under the longest observation. 3. The maxillary mucous membrane of the rabbit consists of multiserial ciliated cylindrical epithelium. The process of carcinogenesis leading to squamous cell carcinoma, after placing of the pellet, was found to consist, in order, of appearance of non-heteromorphous epithelial cell in the epithelium of the base of maxillary sinus, proliferation of non-heteromorphous squamous epithelium, intensification of atypism and polymorphism, atypical proliferation of squamous epithelium, and formation of squamous cell carcinoma.
- 九州歯科学会の論文
- 1978-09-30
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- 9, 10-Dimethyl-1, 2-Benzanthracene による家兎上顎癌形成過程の病理組織学的研究 : 主論文の要旨
- 9, 10-Dimethyl-1, 2-Benzanthracene による家兎上顎癌形成過程の病理組織学的研究