ヒト口蓋腺の oncocyte 出現に関する病理組織学的研究
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概要
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Oncocytes, epithelial cells characterized an abundant, granular and deeply acidophilic cytoplasm, are found in a variety of organs. Generally, oncocytes occur singly or in small clusters and appear to increase in frequency with advancing age. These cells can be found not only in normal salivary gland tissue but also in many tumors, and several salivary gland tumors (Warthin's tumor and oncocytoma) consist primarily of oncocytes. While the morphology of oncocytes in neoplasm of the salivary glands and in normal salivary glands had been characterized, there are very few studies about the systematic examination of oncocytes in normal salivary glands. And the genesis and the biologic significance of oncocytes remain still obscure. In this study, the appearance and the histological pattern of oncocytes in human palatine salivary glands have been examined systematically, and the possible mode of development and the significance of these cells are discussed. The results were as follows : 1) One hundred and sixty four cases of clinically normal palatine salivary gland obtained from autopsized patients of various age, were histologically investigated for oncocytes. These were unselected persons who died of various diseases. Oncocytes were found in 143 persons (87.2%) who ranged from 2 months to 83 years of age. Oncocytes were observed in a few cases before the age of twenty, occurring thereafter most commonly and in greater number in elder cases. The frequency was slightly higher in males than in females. 2) The frequent presence of oncocytes was noted in the canalicular system, especially in large intralobular ducts and interlobular ducts followed by smaller intralobular ducts and acini. These cells were found less often even in the excretory ducts. 3) Oncocytes were usually seen in several areas of the sections studied from each case. As for the location of oncocytes appeared in many cases, they were distributed widely and were noted to increase in distribution with age of the individuals. 4) In both ducts and acini, oncocytes were generally gathered in small groups, but also occurred singly. Some of ducts lined by oncocytes were dilated and contained eosinophilic granular materials, and others showed infolding and stratifying of these cells. These multiplicated patterns of oncocytes in the duct wall were more frequently found in the cases over 50-year-old. 5) In 67 of 143 oncocyte-positive cases (46.9%), the oncocytes appeared to form areas of the probable proliferation including the various patterns, that is, stratification, cyst formation, papillary projection, adenoma-like lesion and groups such as microtubular or acinar appearance. Sometimes several areas of these proliferative lesions of oncocytes were seen in different fields in one section. And such foci were found more frequently in older cases. 6) It was not possible to observe the definite relation between the presence of oncocyte and the other histological change of palatine salivary gland such as glandular atrophy, inflammatory change, regenerative process and so on. 7) From the above-mentioned histological investigations of the oncocytes of palatine salivary glands, it is assumed that the occurrence of oncocyte has some relationship with the aging. Furthermore this possibility is enhanced by the observations that oncocytes not only appeared in increasing number with advancing age, but also more widely distributed and more frequently showed the proliferative lesions in older cases. Because of the fact that the appearance of oncocyte was no relevant to any pathohistological changes of palatine salivary gland such as atrophy, it is assumed that the development of oncocyte would be influenced by the systemic factors rather than the local factors. So, in order to clarify the genesis and the distinct significance of oncocyte, it is necessary to investigate further the occurrence of oncocyte in other salivary glands of the same person, and also to examine the other metaplastic changes simultaneously.
- 九州歯科学会の論文
- 1977-07-31