片側顎下唾液腺摘出後の残存大唾液腺の組織学的変化に関する実験的研究

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In our clinical practice, we occasionally perform the operation of unilateral removal of the submandibular gland in treating the submandibular diseases, malignant, benign tumors or chronic, specific inflammations. In such cases, it seems to be very interesting how the remaining major salivary glands behave histologically. Little work has been done, however, which observes the histological behavior of the remaining major salivary glands after unilateral removal of the submandibular gland. 33 adult mongrel dogs were used for the experiment and the patho-histological changes in the remaining major salivary glands, contralateral submandibular, bilateral sublingual and bilateral parotid glands, were studied during the period from the 1st to the 180th day after removal by trying the H-E, PAS, AB (pH 2.5) and AB (pH 1.0) staining. The results obtained are summarized as follows : 1. The change in the remaining submandibular gland was recognized 3-21 days after removal with a certain extent of increase in size in the serous cells of the demilunes. And the change reached its peak on the 5th day of removal. The nuclei showed tendency to increase in size 3-14 days after removal. In this period, PAS, AB (pH 2.5) and AB (pH 1.0) positive granules contained in the serous cells of the demilunes were found to be homogeneously distributed in the whole cell, which suggested the increase of PAS, AB (pH 2.5) and AB (pH 1.0) reactive substances, coincident with increase in size of cell. 2. In the period when the serous cells of the demilunes were found to be increasing in size, the mucous cells of the remaining submandibular gland maintained their normal states, except that the morphological irregularity was seen in the terminal portions. And they still proved to maintain the normality by the PAS, AB (pH 2.5) and AB (pH 1.0) staining. 3. As for the ductal system of the remaining submandibular gland, obvious changes were not observed. 4. There were 3 changes in the remaining sublingual glands ; the increase of mucous terminal portions which were observed continuously from the 3rd to 180th day of removal, the enlargement of the lumens in the mucous and the serous terminal portions which were observed 3-28 days after removal and finally the enlargement of the small ducts which were observed 1-21 days after removal. 5. In the remaining parotid glands, obvious systematic changes couldn't be observed at all. In many cases, they maintained their normality. It may be concluded from these observations that after unilateral removal of the submandibular gland, the changes appear on the gland cells which are in the deepest connection from the chemical quality with the removed salivary gland cells. And this would also suggest the compensatory activity of these gland cells.
九州歯科学会の論文
1977-03-31

片側顎下唾液腺摘出後の残存大唾液腺の組織学的変化に関する実験的研究

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