口腔癌患者における末梢血リンパ球 Subpopulation の変動に関する臨床的ならびに実験的研究
スポンサーリンク
概要
- 論文の詳細を見る
From the immunologic competence viewpoint, fluctuation of lymphocytes' subpopulation in the patients with oral carcinoma was examined for the purposes of securing the clinical status, investigating the effect after therapy and foreknowing the prognosis. Objects were composed of 46 patients with oral carcinoma (including the cases with long survival time), 28 patients with oral benign diseases, and 43 healthy controls. In addition, the fluctuation following the progress of the tumors in Vx2 carcinoma bearing rabbits was also examined experimentally. The results were summarized as follows. 1. In the healthy controls, differences of T, B-cell levels (percentage, count) with ageing was observed. Especially, in the both percentages of T, B-cells, the significant difference was recognized between 20 years group of carcinoma age in the healthy controls. 2. The remarkable low count (number/mm^3) of B-cell population in the patients with stomatitis was often observed. 3. T-cell level in untreated oral carcinoma group (fresh cases) was remarkably low, but B-cell level equaled the controls'. In percentages of B-cell, most cases indicated higher level. 4. T-cell level in squamous cell carcinoma was low. However, in adenocystic carcinoma, it did not indicate as low. 5. In tongue carcinoma (only squamous cell carcinoma), a decrease in T, B-cell counts was recognized. 6. With the clinical progress of oral carcinoma, a decrease in T-cell level was observed, too. 7. In the cases with survival time over 2 years after therapy for oral carcinoma, the percentage of T-cell indicated significantly low count. 8. T-cell level in the effective group (squamous cell carcinoma) of treated oral carcinoma indicated an ascending tendency with time after treatment. On the other hand, T-cell level in ineffective group indicated a descending tendency gradually. So, in T-cell count immediately after therapy, and in T-cell percentage on 60th day after therapy, there were significant differences between both groups. 9. The cases that indicated, in T-cell count, at least the level existed before treatment or near the level on 60th day after treatment were of convalescent in prognosis generally. But, at one time after treatment, the cases that indicated descending percentage of 50 or more than the count before treatment were dead sooner. 10. Rabbits' T-cell levels after transplantation of Vx2 carcinoma indicated a descending tendency accompanied by the progress of tumor. Five weeks after transplan tation, they indicated the T-cell count in descending percentage of 50 or more and died of the tumor. On the other hand, percentage of B-cell indicated an ascending tendency with time. But it's count did not indicate any definite tendency.
- 九州歯科学会の論文
- 1977-01-31
著者
関連論文
- 17. Bleomycin の味覚乳頭への影響について(一般講演抄録)
- 14. VX_2 癌移植家兎の血漿中銅および亜鉛量について(第 37 回九州歯科学会総会講演抄録)
- 外傷性嵌入歯牙に起因したと思われる上顎洞炎の 1 例
- Oral-facial-digital syndrome の 1 亜型
- 27. 口腔癌患者における末梢血リンパ球 subpopulation に関する研究(第 3 報) : VX_2 担癌 Rabbit について(第 36 回九州歯科学会総会講演抄録)
- 18. 口腔癌患者におけるリンパ球の Subpopulation について
- 口腔癌患者における末梢血リンパ球 Subpopulation の変動に関する臨床的ならびに実験的研究 : 主論文の要旨
- 口腔癌患者における末梢血リンパ球 Subpopulation の変動に関する臨床的ならびに実験的研究
- 口腔領域疾患におけるリンパ球Subpopulationに関する検討 (第1報)