マウスにおけるブドウ球菌の L-form の誘導に関する実験的研究
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概要
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Isolation of L-form variants of pathogenic bacteria has recently been confirmed in the pus of infected lesions of mouth and these variant cells have been suspected to be associated with the maintenance and chronicity of such infection. The author undertook to make inoculation of staphylococci on the tissues of kidney and gingiva in mice for the purpose of obtaining L-form variants of inoculated organisms. The strain of Staphylococcus aureus, 131-1 was inoculated on these tissues either after the animals were given sufficient amount of penicillin or without any such treatment given beforehand. Results obtained were summarized as follows. 1. Formation of gingival abscess following infection with Staphylococcus aureus 131-1 was observed to occur in all 10 animals used which were not given penicillin beforehand, while 5 out of 10 animals which were pretreated with penicillin developed gingival abscess. 2. Induction of L-form variants of staphylococcus within the gingival tissues could not be observed in mice which were either left non-treated with penicillin beforehand or given the drug after establishment of infection in gingiva. 3. Successful induction of L-form variants in the gingival tissues could be observed when the animal was treated with penicillin before the bacterial infection. 4. Visual observation on the process of abscess formation in the kidney tissues by staphylococcal infection revealed that the kidneys of both animal groups either nontreated with penicillin or treated with it after establishment of infection produced 6 to 13 spots of abscess and reflected certain effect of penicillin administration. 5. Induction of L-form variants of staphylococci in the infected kidney could be observed in all animal groups studied. However, recovery of L-form variants was most favorable in mice which were treated with penicillin prior to the bacterial infection. 6. The foregoing results would strongly suggest that penicillin administration plays an important role in the production of L-form variants within the infection focus of animals.
- 九州歯科学会の論文
- 1974-05-31