Evaluation of Arrhythmogenic Substrate in Patients With Hypertrophic Cardiomyopathy Using Wavelet Transform Analysis
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概要
- 論文の詳細を見る
Background Hypertrophic cardiomyopathy (HCM) is thought to have a microvolt-level electrical disarrangement in the myocardium that leads to ventricular tachyarrhythmias and sudden cardiac death. Although signal-averaged electrocardiography (ECG) has been used to detect late potential as a parameter of electrical instability, its predictability is not high. The focus of the present study was the ability of high-resolution wavelet transform from beat-to-beat analysis to detect arrhythmogenic substrates and to evaluate its relationship to the severity of ventricular tachycardia. Methods and Results The study group comprised 50 healthy subjects and 50 patients with HCM. The filtered-QRS duration from the signal-averaged ECG, the high-power duration (HPD) and number of disarrangement points (NDP) from the wavelet-transform ECG were measured. When HPD was defined >114 ms and/or NDP >9 points as abnormal, the sensitivity and specificity for ventricular tachycardia was 93.8% and 79.4%, respectively. When a mean±standard deviation of the HPD in normal subjects was defined as normal, 93.8% of patients with a positive late potential were out of the normal range. Conclusions The newly developed color-display 3-dimensional wavelet transform system showed good time-frequency resolution in analyzing every single beat without signal-averaging. The analysis could be used to detect arrhythmogenic substrates in patients with HCM.
- 社団法人日本循環器学会の論文
- 2005-12-20
著者
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Tanaka K
The First Department Of Internal Medicine Nippon Medical School
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Takano T
Intensive & Cardiac Care Unit Nippon Medical School
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Takano Teruo
First Department of Internal Medicine, Nippon Medical School
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Takayama Tadateru
Tokyo CCU Network Scientific Committee
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Takano Teruo
Tokyo CCU network Scientific Committee
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Takano Teruo
日本医科大学附属第二病院 健康管理科
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Yodogawa Kenji
Cardiovascular Center Chiba-hokusoh Hospital Nippon Medical School
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Yodogawa Kenji
First Department Of Internal Medicine Nippon Medical School
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Takayama Hideo
The First Department Of Internal Medicine Nippon Medical School
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KATOH Takao
First Department of Internal Medicine, Nippon Medical School of Tokyo, Japan
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TAKAYAMA Hideo
First Department of Internal Medicine, Nippon Medical School
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Katoh Takao
First Department Of Internal Medicine Nippon Medical School
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Takano Teruo
Division Of Cardiology Hepatology Geriatrics And Integrated Medicine Department Of Internal Medicine
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Takano Teruo
First Department Of Internal Medicine Nippon Medical School
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Yodogawa Kenji
1st Department Of Internal Medicine Nippon Medical School
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Takano Teruo
Department Of Lnternal Medicine Nippon Medical School
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Takayama Hideo
Division Of Cardiology Tohsei National Hospital
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