腎Adenosinetriphosphataseに依る實驗高血壓(第1報) : 透析腎Adenosinetriphosphatase 連續靜注に依る昇壓効果及び組織變化

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概要

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• Previous experiments by maekawa and his coworkers showed that "dialyzed Kidney-ATPase" had a marked pressor effect when injected intravenously in rabbits and dogs, and it supported Maekawa's postulation that the disturbance of the ATP-ATPase system is the real cause of hypertension.In this experiment, the pressor effect of repeated intravenous injections of this material and the influence on the kidney and cardiovascular system were further investigated in dogs.Six adult mongrel dogs of 8 to 18 kg. body weight, one male and 5 female, were used. Two of them died after the first injeciton of dialyzed Kidney-ATPase. Remaining 4 dogs were treated daily or every other day with intravenous injection of 20 to 90c.c. dialyzed Kidney-ATPase for 9 to 25 days.Mean blood pressure was occasionally measured by a mercury manometer on the femoral artery immediately before and after injection. In two dogs PAH and sodium thiosulfate clearance were performed before and after injection of this material. In the two died animals, autopsy was performed on the following day. Remaining four dogs were killed by bleeding for autopsy after experiment. The tissues selected for microscopic examination were lung, heart, liver, spleen, kidney and intestine. These tissues were fixed in 10% formalin soluiton, embedded in paraffin and stained with hematoxylin-eosin and, moreover, the heart with Weigert-VanGieson stain.The results were as follows : 1. Blood pressure rose after each injection of dialyzed Kidney-ATPase. Elevation of the mean pressure was 20 to 60 mm.Hg, and it did not decrease by repeated injections so far as the activity of the dialyzed Kidney-ATPase was not abolished.2. RPF and GFR decreased markedly immediately after injection of this material and thereafter improved grdually.3. Two dogs died after the first injection of 25 and 60 cc. of dialyzed Kidney-ATPase showed a conspicuous hemorrhage in the lungs and less severe in the heart muscles and kidneys.4. In four dogs treated with repeated intravenous injections of dialyzed Kidney-ATPase, the most remarkable histological changes were found in the kidney and heart. In the kidney thickened degenerated wall of the arterioles and the small arteries and cell infiltration around the afferent arterioles were most conspicuous. Degeneration of the glomeruli, thickening of the glomerular capsules, inclusion of hyaline substance in the glomerular space and slight degeneration of the tubuli were found occasionally. In the heart thickening and cell infiltration of arteriolar wall, intimal and medial thickening of the arteries with degeneration were observed.It is concluded that repeated injection of dialyzed Kidney-ATPase has a pressor effect in dogs and that they seem to induce the fragility or the degenerative changes of arterial and arteriolar walls.

• 社団法人日本循環器学会の論文
• 1957-12-20

著者

• 柏井 忠治郎

  京都大學醫學部内科學第三講座

関連論文

• 腎Adenosinetriphosphataseに依る實驗高血壓(第2報) : Post腎Adenosinetriphosphatase高血壓及びその脈管變化
• 腎Adenosinetriphosphataseに依る實驗高血壓(第1報) : 透析腎Adenosinetriphosphatase 連續靜注に依る昇壓効果及び組織變化

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