冠循環の神經性調節に關する研究(第1報) : 迷走神經中樞端刺激による冠流血量の變化 : 特に血壓變動との關係に就て

概要

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It has been widely known that the stimulation of the proximal end of the vagal nerve is followed by circulatory and respiratory reflexes. On the other hand, it has been suggested that reflexes to the coronary vessels from the visceral organs such as stomach, gallbladder and from the carotid sinus are carried through the cervical vagal nerve. In the persent paper, changes in coronary blood flow by the stimulation of the proximal end of the vagal nerve are reported.Coronary blood flow was measured by rotameter, in anesthetized (with sodium thiopental, 0.03-0.05g/kg intravenously) open-chest dogs weighing 10-15 kg. As shown in Fig. 1 (A), a speically designed cannula (Fig. 1 (B)) was inserted into the ostium of the left coronary artery, thus, a self-perfusing system to the left coronary artery from the right femoral artery was established. A typical calibration curve with rotameter was shown in Fig. 2. The calculated coronary vascular resistance was led from the relationship CVR=<BP>^^^-/CBF, where CVR represents coronary vascular resistance, <BP>^^^-, means blood pressure and CBF, coronary blood flow. The electrical stimulation of the nerve was carried out with spyky wave produced by thyratron. It was continued for 10-15 seconds with frequency of 15-30 cycles per second and intensity of 0.5-30 volts.
社団法人日本循環器学会の論文
1957-12-20