電氣的収縮期間に關する研究(第4報) : 第2編心臓仕事量とQT時間との關係に就ての實驗的研究 : 第2章諸種藥物作用下の摘出蟇心臓に於ける實驗

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On the isolated toad heart the author studied the relationships between the QT interval and the heart work, comparing before with after the addition of various medicaments (Digitalis, Sekigaigoseishi-kiso, Chloralum hydratum, Aethylalkohol, Bile of toad, 1/2 Ca Ringer's Solution and 2K 1/2 Ca Ringer's Solution).(1) When the heart work was increased after the addition of the medicament, the QT interval was prolonged, unchanged or shortened according to the kind and the concentration of the medicament.(2) When the heart work was unchanged after the addition of the medicament, the QT interval was prolonged or shortened after the addition.(3) When the heart work was decreased after the addition of the medicament, the QT interval after the addition was shortened in the majority of cases, but prolonged in some cases.(4) From the above-mentioned data, it may be concluded as follows. Namely, (i) on the toad heart under the action of the medicament to influence the heart function, the QT interval and the heart work are not uniformally related. (ii) Consequently, under the action of the medicament to influence the heart function, not only the QT interval, but also another factor (the electric quantity in unit time), as considered from "Chaindoublets Theory (Maekawa)", have to be taken into consideration in order to judge the change in the heart work.
社団法人日本循環器学会の論文
1956-12-20