心筋燐脂質と心筋障碍との關係に就いての實驗的研究 : 心筋セァリンに依るアレルギー性心筋炎
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In regard to the determinant molecular group of antigen in allegic reactions, Prof. Dr. MAEKAWA pointed out the phosphatide, especially cephalin-fraction as its determinant one on the basis of experimental "Erythron-Allergy". In this report, in order to study the problem in the determinant molecular group of antigen in the experimental myocarditis caused with myocardium phosphatide the author extracted two fractions, from the myocardium phosphatide.i.e., cephalin- and lecithinfraction In cephalin group, consisted of 3 rabbits, the mixture of cephalin (1〜3mg) and bovine serum (2ml per kg of body weight) were injected seven times every other day, and in lecithin group, consisted of 4 rabbits with the mixture of lecithin (10mg) and bovine serum (2ml per kg of body weight) in the same way. Seven days after the last injection they were killed, and their organs were investigated histologically.Clinically body weight and urine were unchanged. In cephalin group lymphocytes decreased at the beginning of the sensitization and then increased, in their hemograms shift to the left and appearance of young cells of myelocytic series were observed. In both groups their serum protein level especially gumma globulin fraction increased, but this increase had no relation to the histological changes of their heart. One rabbit serum in cephalin group showed T-peak electrophoretically.The allergic changes of all rabbits in cephalin group were remarkable, i.e., the panarteriitis from middle big arteries to arterioles were found. Intima and media of coronary arteries hypertrophied and the intimagranuloma were found, thereby the cavity became narrow or closed entirely. The cell infiltrations, chiefly consisted of plasma cell, were found around the coronary arteries and in the perivascular myocardium. These findings were similar to the allergic granuloma by KLINGE. On the contrary in lecithin group only two of four rabbits showed these changes in their heart, however, these changes were slighter than those three in cephalin group. Lung, liver, spleen were unchanged but in a few rabbits in both groups inspecific nephritis occurred.There were no essential difference between my result with bovine myocardium cephalin, NODA's result caused with rabbit myocardium phosphatide and ARAKI and MORISAWA's result caused with human myocardium phosphatide, therefore, the myocardium cephalin has no species-specificity.Consideration of the results reported above lead me to the conclusion that the myocardium cephalin is the determinant molecular group of antigen among the myocardium phosphatide.
- 社団法人日本循環器学会の論文
- 1955-12-20
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