Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system
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概要
- 論文の詳細を見る
Cytochrome P450s (P450) metabolize arachidonic acid (AA) to hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs). Among these eicosanoids, 20-HETE is formed in a tissue and cell-specific fashion and plays an important role in the regulation of vascular tone in the brain, kidney, heart and splanchnic beds. 20-HETE is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells. It depolarizes VSM by blocking the open-state probability of Ca^<2+>-activated K^+-channels. Inhibitors of the formation of 20-HETE block the myogenic response of renal and cerebral arterioles in vitro and autoregulation of renal and cerebral blood flow in vivo. The formation of 20-HETE in vascular smooth muscle is stimulated by angiotensin II, endothelin and norepinephrine and is inhibited by nitric oxide (NO). 20-HETE also stimulates mitogenic and angiogenic responses in vitro and in vivo. Changes in the production of 20-HETE have been observed in ischemic cerebrovascular diseases, cardiac ischemia-reperfusion injury, kidney diseases, hypertension, diabetes, uremia, toxemia of pregnancy. The physiological and pathophysiological role of 20-HETE in the regulation of vascular tone are being revealed by the use of newly developed inhibitors of the synthesis of 20-HETE and 20-HETE analogs. The present review summarizes recent findings implicating a critical role for 20-HETE in altering cardiovascular function in a variety of pathological conditions.
- 日本平滑筋学会の論文
著者
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Roman Richard
大正製薬
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Roman Richard
Department of Physiology, Medical College of Wisconsin
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MIYATA Noriyuki
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.
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Roman Richard
Department Of Physiology And Medicine And Kidney Disease Center Medical College Of Wisconsin
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Miyata Noriyuki
Medicinal Pharmacology Laboratory Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.
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Miyata Noriyuki
Medicinal Research Laboratory Taisho Pharmaceutical Co. Ltd.
関連論文
- PE-187 The Interaction of NO and 20-HETE in the Reduction of Cerebral Blood Flow Following Subarachnoid Hemorrhage in Rats(Cerebrovascular circulation/Stroke-2 (IHD) PE32,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japan
- Increased Excretion of Urinary 20-HETE in Rats With Cyclosporine-Induced Nephrotoxicity
- Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system
- Cytochrome P450 4A Isoform Inhibitory Profile of N-Hydroxy-N'-(4-butyl-2-methylphenyl)-formamidine (HET0016), a Selective Inhibitor of 20-HETE Synthesis(Pharmacology)
- Suppression of AGE Precursor Formation Following Unilateral Ureteral Obstruction in Mouse Kidneys by Transgenic Expression of α-Dicarbonyl/L-Xylulose Reductase