大気圧化学イオン化質量分析法におけるアセチル誘導体化による感度向上(<特集>質量分析法の応用技術)

概要

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A method of increasing the detection response by acetyl-derivatization on atmospheric pressure chemical ionization-mass spectrometry (APCI-MS) has been investigated. By acetylation on compounds having primary alcohol, primary amine and phenolate, it was found that the detection responses of their acetylated forms were increased by 2 to 5 fold over their intact forms. This suggests that acetyl-derivatization was an effective method of increasing response on APCI-MS for compounds having these groups. A possible reason is that acetylation caused increased proton affinity (PA). So, PA should be well considered when trying to increase the response on APCI-MS by derivatization. This acetyl-derivatization method seems promising for increasing the response on LC/APCI-MS.
社団法人日本分析化学会の論文
1996-06-05