化学発光検出高速液体クロマトグラフィーを用いたヒト尿及び毛髪からの覚せい剤分析に関する研究

概要

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An HPLG/chemiluminescence detection method of analyzing methamphetamine (MA), which is the most frequently abused illegal drug, and its metabolites, was developed. Analyses were performed using urine and hair samples from MA addicts. The following results were obtained. First, MA and its metabolites, including glucuronide conjugates, were detected in 2 ml of urine; also, this method could reveal the present ratio of MA and its metabolites in the urine of MA addicts. Second, this method allowed the detection of MA and its major metabolite, amphetamine (AP), using only a single hair, and was shown to be an excellent analytical method when the collection of a large quantity of hair is difficult. Third, hair was shown to be an excellent sample for proving drug use based on considerations of the results of the analysis of hair and urine samples together with the situation of MA use. Fourth, since this analysis can be performed using only a single hair, the black hair and white hair of addicts could be separately analyzed; it was found that the MA and AP contents of white hair are lower than that of black hair, suggesting the affinity of these compounds with melanin. Fifth, it was demonstrated that the contents of MA and AP decrease after permanent wave, dye and decolorant treatments of natural black hair of addicts containing these compounds.
社団法人日本分析化学会の論文
1999-07-05