高分子界面活性剤を利用するミセル動電クロマトグラフィー及びそのオンライン質量分析接続に関する研究

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In this thesis, the author reports further developed techniques of MEKC; use of polymer surfactants as pseudo-stationary phases and direct coupling between MEKC and MS. If we can develop new pseudo-stationary phases having advantages over conventional monomer surfactants, MEKC will be a more useful and powerful separation technique. One purpose of this thesis was a basic study of amphiphilic copolymers as pseudo-stationary phases in MEKC. Polymer surfactants are promising pseudo-stationary phases for the direct coupling of the conventional MEKC with ESI-MS without special devices. Another purpose of this thesis was a basic study of the onqine coupling of the conventional MEKC with ESI-MS using polymer surfactantS. Several advantages of polymer surfactants, including zero CMC, unique selectivity, and MS detection, were verified and polymer surfactants were given a place in the practical and useful pseudo-stationary phase for MEKC. Several techniques presented in this thesis for MEKC-MS include Esf using polymer surfactants as pseudo-stationary phase and ESI combined with the partial filling technique. Each technique gave promising results in this field.
社団法人日本分析化学会の論文
1999-11-05