ビタミンB_2欠乏シロネズミのトリプトファン代謝におけるキヌレニン投与に対するビタミンB_23型負荷の影響について

概要

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After an oral administration of L-kynurenine to riboflavin-deficient or normal rats, free riboflavin, FMN and FAD were injected subcutaneously and urinary excretion of anthranilic acid, xanthurenic acid, N-methylnicotinamide and kynurenine were examined. In riboflavin-deficient rats, given with kynurenine only, a considerable amount of anthranilic acid, followed by kynurenine, xanthrenic acid, and of a small amount of N-methylnicotinamide were excreted in the urine, while in normal rats any appreciable change was recognized. When kynurenine and riboflavin were administrated, urinary anthranilic acid and kynurenine changed a little by the injection of free riboflavin, decreased by FAD, considerably decreased by FMN. A decrease was observed in xanthurenic acid excretion by the injection of riboflavin and FAD, especially by FMN. N-methylnicotinamide increased by free riboflavin and FAD, remarkably increased by FMN.
日本ビタミン学会の論文