疾病時におけるビタミンB_6附燐能の研究 : (I)実験的肝障害時における肝ピリドキサール燐酸の変動

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In acute and chronic CCl_4 damage, the content of pyridoxal phosphate of rat liver was found to decrease. It was demonstrated that pyridoxal phosphate was chiefly concentrated in supernatant and mitochondrial fractions of normal rat liver cells. In acute CCl_4 damage, the decrease of pyridoxal phosphte was most significant in either supernatant and mitochondrial fractions. The synthesis of pyridoxal phosphate in vivo as well as in vitro was impaired in damaged liver, but no significant difference was observed in pyridoxal phosphate-decomposing activity between normal and CCl_4 damaged rat liver.
日本ビタミン学会の論文