パントテン酸欠乏シロネズミにおけるビタミンB_<12>の利用および代謝

スポンサーリンク

概要

• 論文の詳細を見る

• The metabolic pattern and the sparing effect of vitamin B_<12> were studied in pantothenic acid deficiency in the rat and the following results were obtained : a) The liver of pantothenic acid deficient rat had higher vitamin B_<12> content than the control, but the plasma vitamin B_<12> level was not elevated in pantothenic acid deficiency. b) Administration of a large dose of vitamin B_<12> to rats receiving suboptimal dose of pantothenic acid had sparing effect on the survival rate. c) Absorption and excretion of radioactive vitamin B_<12> was not impaired in pantothenic acid deficiency. d) Radioactive vitamin B_<12> introduced either by intestinal absorption or by injection was retained more in the liver on gram basis in pantothenic acid deficient rats than the normal. It was proposed from the evidence presented that these two vitamins are closely interrelated in the intermediary metabolism, and that in pantothenic acid deficiency the utilization of vitamin B_<12> is impaired to result in elevated liver vitamin B_<12> levels.

• 日本ビタミン学会の論文

著者

• 奥田 邦雄

  山口県立医科大学第1内科

• 奥田 邦雄

  山口県立医科大学第一内科教室

関連論文

• 6.CAT類の臨床(VI.人体における実験ならびに臨床応用)(S-Carbalkoxythiamineにかんする小委員会報告)
• 70.ビタミンB_の腸管吸収に及ぼすEDTAの影響(第14回日本ビタミン学会大会研究発表要旨)
• パントテン酸欠乏シロネズミにおけるビタミンB_の利用および代謝

スポンサーリンク