エチルビタミンB_1の生理作用

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Recently Aramaki found that 2-ethylthiamine had nearly the same growth-promoting activity as thiamine in young rats, confirming the result obtained by Schulze. But Aramaki, and Kusch et al. observed that when rats were injected with ethyl thiamine their liver showed only a little increase in the cocarboxylase activity, and Aramaki et al. confirmed that the cocarboxylase activity of ethylthiamine pyrophosphate was only one twelfth to one fifteenth that of thiamine pyrophosphate. Previohsly we found that the daily injection of 20μg of ethylthiamine had the same growth-promoting action as that of 20μg of thiamine for mice fed with thiamine deficient diet for 18 days. Moreover, the liver homogenate of mice injected with ethylthiamine for a long time showed nearly the same endogenous respiration as that of mice treated with thiamine. Using washed liver homogenate of thiamine deficient mice we compared the respiration-stimulating activity of ethylthiamine pyrophosphate with that of thiamine pyrophosphate and confirmed that the former had a much lower activity than that of the latter. Finally, using the brains of thiamine deficient mice we compared the catatorulin effect of ethyl thiamine with that of thiamine and found that here again the activity of the former was much weaker than that of the latter. The above results could not explain the reason of growth-promoting effect of ethylthiamine.
日本ビタミン学会の論文